Grushin

Research group

FULL REPORT

Research abstract

Our research spans organic and inorganic chemistry with emphasis on metal complex catalysis and mechanistic studies.  The main focus of the group is on new chemical transformations toward the development of highly challenging and practicable processes as well as deep understanding of elementary steps involved in the catalytic loop.  Many of our projects are centered on organometallic fluorine chemistry, a new and exciting area for research.  Our ultimate goal is the development of efficient methods for highly chemo- and regioselective, practicable fluorination, trifluoromethylation, and fluoroalkylation reactions of organic molecules with metal reagents and catalysts.  Our other research interests include the synthesis of homogeneous catalysts, fine chemicals from renewable resources, inert bond activation, and new metal-catalyzed reactions of otherwise unreactive aromatic substrates.

Topics addressed

  • Organometallic fluorine chemistry
  • New, Highly Efficient, Simple, Safe, and Scalable Synthesis of [(Ph3P)3Ru(CO)(H)2]

Articles

“Cupration of C2F5H: Isolation, Structure, and Synthetic Applications of [K(DMF)2][(t-BuO)Cu(C2F5)].  Highly Efficient Pentafluoroethylation of Unactivated Aryl Bromides”
J. Am. Chem. Soc. 2013,135, 12584-12587.
Lishchynskyi, A.; Grushin, V. V.

“The Critical Effect of the Countercation in the Direct Cupration of Fluoroform with [Cu(OR)2]–“
Angew. Chem. Int. Ed. 2013, 52, 11637-11641.
Konovalov, A. I.; Benet-Buchholz, J.; Martin, E.; Grushin, V. V.

“Nucleophile-Catalyzed, Facile, and Highly Selective C−H Activation of Fluoroform with Pd(II)”
J. Am. Chem. Soc. 2013, 135, 16837-16840.
Takemoto, S.; Grushin, V. V.

“New, Highly Efficient, Simple, Safe, and Scalable Synthesis of [(Ph3P)3Ru(CO)(H)2]”
Organometallics 2013, 32, 4440-4443.
Samouei, H.; Grushin, V. V.

“Trifluoromethylation of Aryl and Heteroaryl Halides with Fluoroform-Derived CuCF3: Scope, Limitations, and Mechanistic Features”
J. Org. Chem. 2013, 78, 11126-11146.
Lishchynskyi, A.; Novikov, M. A.; Martin, E.; Escudero-Adán, E. C.; Novák, P.; Grushin, V. V.

“Trifluoromethylation”
Science of Synthesis: C-1 Building Blocks in Organic Synthesis 2. van Leeuwen, P. W. N. M., Ed.; Thieme: Stuttgart, 2013, 367-408.
Lishchynskyi, A.; Novák, P.; Grushin, V. V.